San Francisco has ruled out four players for Sunday's Week 5 game against Seattle, while cornerback Upton Stout and defensive end Mykel Williams are questionable.
The 49ers' injury report lists defensive end Nick Bosa with knee and calf issues, fullback Kyle Juszczyk with a knee injury, safety Marques Sigle with an ankle injury and defensive tackle James Thompson with an ankle injury as out. Stout, who has a shoulder injury, missed Friday's practice after limited participation Thursday.
Seattle has ruled out running back Zach Charbonnet, cornerback Julian Neal and linebacker Chazz Surratt. Wide receiver Irvin Charles and running back George Holani are questionable for the game at Lumen Field.
Williams practiced fully Friday as he works back from an ACL injury. Coach Kyle Shanahan said he would be activated from the physically unable to perform list Saturday. Wide receiver Mike Evans, limited Friday with a rib injury, is expected to play Sunday.
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